During his long political career, Semynozhenko has been the head of several different parliament committees, including the Parliament Committee for Social, Science and Technology and Humanitarian Development and the Ukrainian Investment Fund for Social Investment Environmental Committee. He has also been elected Vice Prime Minister of Ukraine three times.

Mr. Semynozhenko firmly believes that his position in government is not nearly as important as the role he plays in, and the impact that he can have on, the future of Ukraine.

Mr. Semynozhenko formed the Ministry of Science and Technology and later became a member of the Committee for selecting the most valuable science and technology project for the Cabinet of Ministers. In his public life, Semynozhenko has authored and championed many new laws that directly lead to the social and economic welfare of the Ukrainian scientific community and the greater population as a whole.

An independent politician, Semynozhenko maintains an opinion considered very valuable to many political leaders, and in 1998 he was awarded the Congressman of the year award. In 2006, he formed and lead the political organization called the Ukrainian Forum. Its purpose is an analysis of national and political trends and their effect on both the Ukraine, and the rest of the world.